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Autoxidation occurs at physiological pH and is initiated by the surrounding free radicals, which autoxidize the phenolic hydroxyls on the curcumin molecule (92)

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An in vivo study included a rat model, found that NAC effectively prevented pulmonary edema and acute kidney injury during sepsis, particularly under mechanical ventilation stress, by preserving mitochondrial function and capillary integrity ( via disulfide bond reduction, reducing platelet aggregation and microthrombi formation, which are central to sepsis-induced organ failure (Liu et al., 2025)